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In a 26-week study, tirzepatide was studied to determine its effect on biomarkers of nonalcoholic steatohepatitis (NASH) and fibrosis in patients with T2DM

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These occurred in 6.5% of participants on Wegovy and 8.0% on placebo, a 20% relative risk reduction

Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 17 trials

The majority of these discontinuations were due to gastrointestinal-related adverse events, primarily occurring during the rapid dose-escalation phase

However, each potential stack requires dedicated scientific inquiry