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GI toxicity hits midstage Sanofi GLP-1 drug as patients drop outfiercebiotech.com

Advantage : Semaglutide Summary and Verdict# Ecnoglutide's biased GLP-1 signaling represents a scientifically novel approach, and SLIMMER Phase 3 data (15.4% weight loss at 48 weeks) are comparable to semaglutide's STEP 1 results (14.9% at 68 weeks)

Scott JS, Bowker SS, Deschoolmeester J et al (2012) Discovery of a potent, selective, and orally bioavailable acidic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acet ic acid (AZD4017)

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The IC 50 values for CQ, artemisinin, and methylene blue were very similar between parasites grown in GR-deficient RBCs and in normal control RBCs (Table 1)

doi: 10.1016/j.tem.2020.01.004