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2025;24(1):e16780

PI/PC-PLC-Independent Effects of Exendin-4 While GLP-1 has been shown to regulate the phosphatidylinositol-phospholipase C (PI-PLC) or phosphatidylcholine-phospholipase C (PC-PLC) activity in mouse pancreatic cells [56], experiments with the PI-PLC inhibitor U73122 or with the PC-PLC inhibitor D609, did not support the involvement of these two pathways in the exendin-4 effects on GCs

Glucagon-like peptide-1 receptor agonists and safety in the preconception period

Neither approach proves universally superior

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Alongside weight loss, the people using oral semaglutide showed better blood sugar improvements and lower cardiovascular risk factors like cholesterol