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"So adding an extra month or two to help with tolerability upfront can help with kind of long-term success." Unanswered questions Several questions remain about the long-term use of the pill, especially on higher doses, and it may not be the best obesity treatment for every patient, experts said

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However, Chu found that activation of p53 alone did not significantly downregulate GSH/GSSG ratio, glutathione levels, and GPX4 activity in human cancer cells