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In addition, a meta-analysis of 1193 patients with baseline SGLT2i use in AMPLITUDE-O and Harmony Outcomes revealed an HR for MACE of 0.78 (95% CI 0.491.24) with SGLT2is and 0.77 (95% CI 0.680.87) without SGLT2is ( P -value for interaction 0.95), and an HR for HHF of 0.34 (95% CI 0.120.96) with SGLT2is and 0.72 (95% CI 0.550.92) without SGLT2is ( P -value for interaction 0.18) [48]

doi: 10.1038/ajg.2011.86 21 DavidL

Whether this translates to humans is debated, but the contraindication is strict

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Patients also often report quicker results with injections compared to weeks or months using oral supplements