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However, in the context of obesity, the effectiveness of leptin in promoting fatty acid oxidation is diminished due to leptin resistance

Xavier Xifr, University of Girona, Spain Updates Copyright 2019 Ratner, Kumaresan and Farb

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Ricks compared GLP-1 uptake to low-cost statins, the most commonly prescribed cholesterol medicines, noting that between 40 and 50 percent of people who should be on them, are on them, which he sees as maybe a ceiling. Reuters reported that he put 50 percent of global weight-loss drug candidates at roughly 500 million people but said today were treating 21 or 22 million, adding that 20-fold production growth will not happen anytime soon. He told Reuters there is no real efficiency gain left, so Lilly has to put in more units of capacity, and described the capex rollout as expensive and slow. Price and access remain central constraints

That is why it is also known as B12 shots