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Known under brand names such as Ozempic and Wegovy, semaglutide is primarily used for treating diabetes but also can be highly effective for weight loss

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Other safety topics clinicians monitor include hypoglycaemia risk (low blood sugar, more common with insulin/sulfonylureas), pancreatitis/gallbladder disease, and eyerelated safety signals

The use of XIGDUO XR for this indication is also supported by evidence from adequate and well-controlled trials of metformin HCl immediate-release tablets in adults with additional data from a controlled clinical trial using metformin HCl immediate-release tablets in pediatric patients 10 to 16 years old with type 2 diabetes mellitus, and pharmacokinetic data with metformin HCl extended-release tablets in adults [see Clinical Pharmacology (12.3) and Clinical Studies (14.1, 14.2)]