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GHK-Cu gentler, works through tissue remodeling vs cell turnover

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One of the biological activities of the centellosides is to be able to stimulate GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells), and especially hyaluronic acid synthesis in our skin

Identification of catalytic nucleophile of Escherichia coli -glutamyltranspeptidase by -monofluorophosphono derivative of glutamic Acid: N-terminal Thr-391 in small subunit is the nucleophile

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Chloroacetamide (ClAA) (Sigma-Aldrich, Saint-Louis) was added to a final concentration of 7.5 mM to alkylate the proteins followed by a 20-min incubation at room temperature in the dark