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Furthermore, the activation of intracellular pathways, such as PI3K/Akt and cAMP/PKA by GLP-1RA contributes to decreased oxidative stress, inhibition of neuronal apoptosis, and improved mitochondrial function

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Based on the technical problems in the prior art, a synthesis method of semaglutide, which is simple and convenient to operate, low in synthesis cost, higher in efficiency and higher in product purity and is more suitable for industrial production, is urgently needed

References Grunfeld C, Dritselis A, Kirkpatrick P