That usually means: A slower titration approach A simpler meal pattern with fewer common IBS triggers during titration weeks Caution with sugar alcohols, high-lactose products, large raw vegetable portions, and very high-fat meals Some people do better when they temporarily lean more "low-FODMAP by default" during dose escalations, then expand once symptoms stabilize
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Retatrutides six-day half-life keeps blood levels climbing for about three weeks after each step, so nausea or a heart-rate response can surface after the dose has already increased