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Gut hormone PYY(3-36) physiologically inhibits food intake

As an example, platelets from G6PD-deficient individuals exhibit reduced G6PD enzymatic activity (30), affecting the availability of reduced glutathione required for platelet aggregation (89) and of NADPH needed for biosynthesis of fatty acids and phospholipids (90) ( Figure 1A-3 )

Furthermore, in colorectal cancer, IGF-2 is critical for cancer stem cell formation and IGF-2 preferentially interacts with insulin receptor isoform A rather than with IGF-1R to accelerate autophagy and metabolic remodeling in colorectal cancer (55)

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