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The sum of evidence suggests that, when detected, the use of GLP-1/GIP agonists is associated with the development of mild DR or a slight worsening of existing retinopathy

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By integrating medicinal chemistry with delivery science, we propose a conceptual framework to optimize target selectivity, enhance cellular uptake, and broaden the therapeutic window, providing systematic guidance for overcoming the bottlenecks of PROTAC in vivo applications

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