Tominaga Y, Hirayama I, Nonaka M, Yano T, Ishii M
Calculations of key parameters of the mitochondrial function were performed, consisting of basal respiration (BR, OCR initial OCR rot/AA ), ATP production (ATP, OCR initial - OCR oligo ), proton leak (PL, OCR oligo OCR rot/AA ), maximal respiration (MR, OCR FCCP OCR rot/AA ), spare respiratory capacity (SRC, OCR FCCP - OCR initial ), spare respiratory capacity [%] (SRCP, MR/BR*100), non-mitochondrial respiration rate (NMRR, OCR rot/AA ), and coupling efficiency [%] (CE, ATP/BR*100)
Summar ML, Koelker S, Freedenberg D, Le Mons C, Haberle J, Lee HS, Kirmse B, European R
Shi A, Xie P, Nielsen LL, Skjth TV, He X, Haugaard SP (2021) Pharmacokinetics, safety and tolerability of once-weekly subcutaneous semaglutide in healthy Chinese subjects: a double-blind, phase 1, randomized controlled trial
Since the skin on hands, feet, and knuckles is thicker and more exposed to environmental factors, improvement takes consistent care over time
Primary endpoint results at 24 weeks: Placebo: 1.6% body weight reduction 1mg retatrutide: 8.7% 4mg: 17.3% 8mg: 22.8% 12mg: 24.2% At 48 weeks, the 12mg cohort sustained 24.2% mean weight reduction
