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The activation of the Nrf2 ARE pathway, subsequently leading to the upregulation of key downstream elements such as NAD(P)H quinone oxidoreductase 1, heme oxygenase 1, and glutathione peroxidase 1, plays a pivotal role in countering oxidative stress [37]

(Source 1) In cases where glutathione demands are high, or there are genetics inhibit glutathione production, glutathione supplementation is often very effective

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In FMT experiments, the protective effect of control-donor microbiota was consistent with restoration of a gut ecosystem enriched in butyrate-related functions [42]