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In addition, it is well known that polarized macrophage, activated neutrophils, and tissue-derived cytokine, as key regulators that link the fibrosis in a variety of diseases [63, 64]

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The EPM is a well-established paradigm for assessing anxiety-like behavior in rodents, involving specific neural circuits, neurotransmitters, and brain regions (Lezak et al., 2022)

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doi:10.1016/j.clnu.2020.09.040 11 Martindale R, Patel JJ, Taylor B, Arabi YM, Warren M, McClave SA