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Cyclodextrin complexation, nanocarriers, polymeric micelles, phospholipid complexation, and nanocrystals have been used to enhance the solubility and bioavailability of luteolin via slowing of the degradation in the blood stream and demonstrating increased dissolution and bioactivity, largely in cancer models [173, 175,176,177,178,179,180,181,182]

Farrell, C

S., Bhattacharyya T

[127] synthesized phospholipid-based gelatin nanoparticles encapsulating basic fibroblast growth factor (bFGF) for nasal delivery to the brain