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Chronic starvation is associated with GH resistance and relatively low IGF-1 levels involving a feedback mechanism, rather than body composition parameters or other circulating factors, e.g., free fatty acid or insulin levels (Stving et al., 1999

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Consistently, miR-145 overexpression in HKCI-C2 cells induced G2-M arrest and apoptosis suggesting that miR-145 has the repressive effect of hepatic malignant growth through negative regulation of IGF-1R

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