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Lorsch ZS, Liddle RA

Mounjaro (tirzepatide) works by activating two hormones involved in appetite and blood sugar regulation: Retatrutide works on three hormones, which is why it is often referred to as a triple-agonist. It activates: The addition of glucagon is what makes retatrutide different

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Allowing at least one inch between injection sites prevents localized reactions and ensures proper drug delivery

The AMPLITUDE-O trial, involving 4,076 patients with T2D and a history of either CVD or kidney disease, participants were randomised to receive efpeglenatide or placebo

A meta-analysis of 12 studies (that included ten cohort and two case-control studies) found no overall change in PDAC risk amongst GLP-1RA users