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doi: 10.1046/j.1365-2826.2000.00446.x 76 TannenbaumG

In contrast, the CysSSH levels in liver and lung tissues of CARS2-deficient heterozygous mice were reduced by more than 50% compared with those of WT mice, highlighting the principal role of CARS2 in CysSSH biogenesis (Zainol et al., 2023)

These findings revise the conventional view of GSH in protein redox and demonstrate that targeted redox manipulation through GSH depletion protects against MASLD

Mechanistically, its claimed effects track the biology of that TB4 motif: regulating actin dynamics, driving cell migration, and supporting new vessel growth and tissue repair

Inflammopharmacol 20:12750 Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

doi: 10.18773/austprescr.2015.018 125 WangW.LiY.MengX