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Abbreviations AIH: autoimmune hepatitis ALP: alkaline phosphatase ALT: alanine aminotransferase AMA: antimitochondrial antibody ANA: antinuclear antibody ASMA: anti-smooth muscle antibody AST: aspartate aminotransferase Bili: bilirubin DILI: drug-induced liver injury HMG-CoA: hydroxymethyl glutaryl coenzyme A reductase HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase IAHG: International Autoimmune Hepatitis Group RUCAM: Roussel Uclaf Causality Assessment Method ULN: upper limit of normal Declarations Acknowledgement This work was made possible by the Herman Lopata Chair in Hepatitis Research

Advances in pharmacogenomics and precision medicine may eventually refine patient selection

Figure 1: Recycling of Hcy in the methionine cycle is enabled by methyl THF, otherwise compromised by the MTHFR gene

That gap matters more than most people realize

The specificity of AOD 9604 for fat metabolism has generated interest in its potential role in weight loss and body composition improvements while minimizing the side effects typically seen with full-scale hGH treatments

Some patients report feeling slightly more fatigued or experiencing mild mood fluctuations when doses are skipped, though these effects are temporary