It works at the cellular level within the fat tissue itself
Optimal timing enhances effectiveness while poor timing can waste a significant portion of each dose
Conclusion In this study, a DEHP degrading strain, Nocardia asteroides LMB-7, was isolated from electronic waste soil
These investigators found that untreated Cushings disease patients had low GH and high IGF-I levels without clinical features of acromegaly, and after surgery with disease remission, serum IGF-I levels normalized

Method Absorption Rate Advantages Disadvantages Oral pills 1.2-40% depending on intrinsic factor Convenient, widely available Poor absorption, especially with age or GI issues Sublingual Slightly better than pills No need for intrinsic factor, easy to use Still less effective than injectable forms In-clinic IM injection Nearly 100% Highly effective, professionally administered Requires clinic visits, potential travel and waiting time At home B12 injection Nearly 100% Highly effective, convenient, no travel needed Requires training, prescription, and comfort with self-injection IV infusion 100% Immediate delivery to bloodstream Most expensive, requires professional administration For many people especially those with serious deficiencies, digestive disorders, or pernicious anemia at home B12 injection offers the sweet spot of effectiveness and convenience

Y. Fan, Y. Gong, P. K. Ghosh, L. M. Graham, and P. L. Fox, Spatial Coordination of Actin Polymerization and ILKAkt2 Activity during Endothelial Cell Migration, Elsevier BV, May 2009. doi: 10.1016/j.devcel.2009.03.009