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The half-life of circulating reduced glutathione (GSH) is approximately 23 hours, but this reflects rapid cellular uptake and oxidation rather than true elimination

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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

Additionally, the expressions of GLUT1, GLUT6, and Ki-67 were downregulated, while SREBP2 expression increased in the treated group (Fig

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