Other Approved and Investigational Uses Polycystic Ovary Syndrome (PCOS): This is an off-label use
GOT1 and GOT2 catalyze the transamination reaction between oxaloacetate and glutamate to produce aspartate and -KG
Fiorentino et al., 2016)
Aoyagi T, Aoyama T, Kojima F, Matsuda N, Maruyama M, Hamada M et al
Statin treatment (rosuvastatin, atorvastatin, fluvastatin, pravastatin) upregulated the gene expression of key enzymes involved in hepatic gluconeogenesis ( G6PC and PCK1 ) resulting in increasing glucose production in the liver, and hepatic insulin resistance
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