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The multi-omics integration paradigm established by large-scale cohort studies such as the Human Microbiome Project, combined with artificial intelligence and biomarker development, has charted the direction toward individualized precision treatment (Margolis et al., 2021), providing a solid scientific foundation for achieving the integrative medicine goal of simultaneous treatment of body and mind. Statements Author contributions BY: Formal analysis, Resources, Writing original draft, Visualization, Writing review & editing, Methodology

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Neuroinflammation is one of the most prominent consequences of microbiotagutbrain axis disruption

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FFAR3, Free Fatty Acid Receptor 3

If hypersensitivity reactions occur, discontinue use of OZEMPIC