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Abbreviations GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: Glucose-dependent insulinotropic polypeptide receptor GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis STEP: Semaglutide Treatment Effect in People with Obesity References Bray GA, Kim KK, Wilding JPH (2017) Obesity: a chronic relapsing progressive disease process
Patients experiencing severe nausea, vomiting, or delayed gastric emptying face higher theoretical risk than those with mild or no GI side effects
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While these events were generally mild and rarely led to treatment discontinuation, this represents a unique side effect profile that prospective users should understand before starting treatment
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Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases
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