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2021 [cited 2022 Sep 27]

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However, the long-term treatment with GLP-1RAs may reduce the insulin levels in both T2DM (122) and prediabetic patients (123), owing to the glycemic normalization and increased insulin sensitivity in these patients

Rather than functioning as independent mechanisms, HSPs, autophagy, mitophagy, the UPS, ERAD, and UPR collectively form a multilayered, compensatory system that preserves protein quality and cellular viability

Activation of specific heterotrimeric G proteins involves different regions of the receptors intracellular loops, primarily the third intracellular loop (8, 50, 68)

The evidence is still early and mostly preclinical, so it should be used only under medical supervision and never as a replacement for standard cardiac care