glutathione peroxidase vs catalase Free Radicals and Oxidative Stress: R&D Systems Superoxide dismutase (SOD), glutathione peroxidase

This article is a systematic review of selenium supplementation trials in AIT

30% or less of the deficiency of the G6PD enzyme leads to hemolysis when exposed to some drugs, like antimalarial (primaquine) medicines

Animal models attempting to replicate the dopaminergic pathology and clinical features of PD have been critical to our understanding of the pathogenic mechanisms of the disease

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

Authors NAE, SJ, MRF, MA, AAA, RA, KD, FH, and MAl

These findings are consistent with previous studies suggesting that Mel and GSH may prevent structural damage in ovarian histoarchitecture by suppressing oxidative stress.10,11,15-18,21,22 Both Mel and GSH are key endogenous antioxidant molecules that neutralize free radicals and preserve tissue integrity by limiting oxidative stress-induced cellular damage.30,31 It has been previously reported that platinum-based chemotherapeutic agents such as carboplatin increase intracellular ROS production, thereby triggering lipid peroxidation (as indicated by elevated MDA levels), inflammatory responses (increased TNF- and IL-6), cellular damage, and apoptosis.2,7,8 In the current study, the increased immunoreactivity of Caspase-3 and NF-B, along with significantly elevated levels of TNF- and IL-6 in the CARB group, indicate that CARB may have simultaneously activated both apoptotic and inflammatory pathways