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Refluxed blood promotes the Fenton reaction, terminating in the production of hydroxyl radical, the most potently destructive ROS

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To address the need for independent validation, we systematically evaluated all lead variants in publicly available POAG GWAS datasets, including UK Biobank (European ancestry), POAAGG (African ancestry), and other published studies identified through the GWAS Catalog

Syed Hamid Habib and Fawad Ali Shah helped in editing and provided critical comments