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Key Pharmacokinetic Differences# The critical difference lies in their albumin binding and metabolic stability: Semaglutide's longer half-life results from three structural modifications: an aminoisobutyric acid (Aib) substitution at position 2 that confers DPP-4 resistance, a C18 fatty diacid (vs C16 in liraglutide) that strengthens albumin binding, and a hydrophilic linker that optimizes the fatty acid orientation