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278,279,280 About 70% of NMOSD cases are caused by AQP4 auto-antibodies, which after entering the nervous tissue damage astrocytic endfeet rich with AQP4 channels

Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

The dosing information for methyl cobalamin injection may vary depending on the individual's age, weight, medical history, and the condition being treated

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