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N Engl J Med (2015) 373:211728

Untested formulations Semaglutide and tirzepatide are FDA-approved as injectables (an oral tablet version of semaglutide is also approved), but the formulations some drug compounding pharmacies are selling in the form of sublingual drops or dissolving tablets have never been studied in clinical trials

The US FDA urges caution around unapproved or compounded GLP-1 formulations that may be unsafe

Analysis: The peptide problem: Hype is outrunning the evidence With flimsy or no evidence that using unauthorized peptide drugs is effective in humans, buying the online and self-injecting is high-risk, uncontrolled human self-experimentation, writes Stuart Phillips

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