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Given the wide popularity of GLP-1 drugs, the public now increasingly recognizes that using medication to treat obesity is as legitimate as using insulin for diabetes or a statin for high cholesterol
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In this context, the activity of preproglucagon-expressing neurons in the NTS is stimulated by afferent vagal inputs that relay satiety signals from the periphery to the brain, such as gastric distention, the induction of peripheral GLP-1Rs or the release of the satiety-associated hormones cholecystokinin and leptin
10.1136/tsaco-2020-000595 86 StrbeS.GojkovicS.KrezicI.ZizekH.VranesH.BarisicI.et al (2021)