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This figure presents the subgroup analysis of the risk for the composite cardiovascular endpoint, stratified by age, gender, race, moderate-to-severe chronic kidney disease (CKD), chronic ischemic heart disease, and diabetes mellitus (DM) control, after propensity score matching

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The models overall significance was confirmed by the likelihood ratio test, Wald test and score test, all of which showed highly significant p-values

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In a post hoc analysis of SURPASS-4, tirzepatide treatment was associated with a significant reduction in composite renal outcome events (time to first occurrence of at least 40% decline in estimated glomerular filtration rate from baseline, end-stage renal disease, renal-related death, or incident macroalbuminuria) compared with treatment with insulin glargine (HR = 0.58

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