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Metabolism & Elimination The metabolic fate of both components involves proteolytic degradation and renal clearance [19]: GLP3 contains DPP-4 resistant modifications (Aib2 residue) providing enzymatic stability Cagrilintide incorporates proline residues reducing fibril formation and improving stability Both peptides undergo gradual proteolytic cleavage to smaller peptide fragments Renal elimination represents the primary excretion pathway for metabolites No significant hepatic metabolism through cytochrome P450 pathways Steady-state concentrations are achieved after 4-5 weeks of once-weekly dosing for both components, with minimal accumulation beyond expected levels based on half-life calculations

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Its antioxidant properties further protective effects on skin cells from oxidative stress by neutralizing free radical damage, which is one of the primary contributors to premature aging and skin damage (5)

IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic variant of human IGF-1 , modified to increase both its potency and half-life