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It has been proposed that -tocopherol can also scavenge superoxide, as suggested by experiments with submitochondrial particles isolated from mice fed with vitamin-E supplemented diet (Chow et al., 1999)

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Many early peptide programs relied on acute or high-dose administration, which produced adverse effects unrelated to therapeutic exposure levels

Neither mechanism produces an instant visual change both operate at the cellular level and become visible only as skin naturally renews itself over successive weeks