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Respiratory symptoms may include nasal congestion, rhinorrhea, sneezing, and shortness of breath (dyspnea)

Artinger, I

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Two investigators (HW and TG) independently performed the data extraction from each publication using a standardized form: publication data, baseline characteristics of the study population (sample size, sex, age, body mass index (BMI), body weight, abdominal circumference, waist-to-hip ratio, visceral adipose tissue (measured by computed tomography, magnetic resonance imaging, or dual-emission X-ray absorptiometry)), duration of follow-up, weight change during treatment and after treatment discontinuation, description of the weight management group and control group

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DAGs activate protein kinase C (PKC) isoforms that serine-phosphorylate and inhibit the insulin receptor substrate 1 (IRS-1), while ceramides activate Protein Phosphatase 2A (PP2A), which dephosphorylates and deactivates Akt, thereby locally exacerbating IR and promoting further atrophy (62)