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From these molar concentrations the status of the GSSG/2GSH couple was calculated using the Nernst equation E h c = 255 30 log ([GSH] 2 / [GSSG]) in mV [26], assuming an intracellular pH of 7.25 for RBCs and a temperature in vivo of 37 C [27]

& Haluzik, M

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doi:10.1016/j.jtauto.2021.100131

The polymer backbone covalently integrates an L-buthionine sulfoximine prodrug to inhibit glutathione biosynthesis, and the nanoparticle matrix encapsulates an elesclomol-copper complex to promote intratumoral copper accumulation

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