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Systemic FXR agonists such as OCA may cause dyslipidemia and pruritus, while selective intestinal FXR activators like Fexaramine can avoid direct hepatic activation, circumvent related toxicity risks, and significantly improve obesity and insulin resistance in animal models ( TGR5 is mainly expressed in enteroendocrine L cells of the distal ileum and colon and can be activated by bile acid agonists, including natural bile acid analogs (such as DCA) and synthetic small-molecule agonists (such as INT-777)
doi:10.1016/j.jaci.2005.09.028
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Dietary antioxidant supplementation of men improves their semen parameters
