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Increased platelet activation along with fibrinogen, plasminogen-activator inhibitor 1 (PAI-1), plasmin-alpha-2-antiplasmin (PAP), and thrombin-antithrombin (TAT) complexes has been observed in healthy human volunteers (20-50 years old) during the morning (0800 h), with increasing concentrations of endogenous tPA, d-dimers, and PT prolongation in the afternoon (Soulban and Labrecque, 1989)