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The field of delivery vehicles encompasses lipid-based, polymeric, and inorganic nanoscaffolds, as well as antibody-PROTAC conjugates (DACs) and aptamer-PROTAC hybrids (APCs), providing multidimensional platforms for crossing biological barriers and achieving antigen-dependent targeting

Gastrointestinal symptoms including nausea, vomiting, diarrhea, constipation, and abdominal discomfortare the most frequently reported adverse effects, occurring in 20-30% of patients (varying by dose and population), particularly during dose escalation

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