CFR, which represents the maximal dilator response to an arteriolar vasodilator, is frequently applied but carries the disadvantage of representing the effects of macro- and microvascular disease ( Further studies are needed with adequate numbers of participants using highly accurate measures of CMF, such as positron emission tomography or cardiac magnetic resonance, to verify the hypothesis of GLP-1 and GLP-1 RAs affecting CMF
It has been demonstrated that semaglutide administered subcutaneously once weekly lowers HbA1c more effectively than liraglutide, dulaglutide, and exenatide once weekly [96]
Below is a summary of the head-to-head studies to date
Metabolism 85 , 250258 (2018)
How will the robust pipeline of new therapies affect access
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