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After reviewing data submitted to the FDAs Adverse Event Reporting System between 2018 and 2024, McCall and his coauthors found that compounded GLP-1 medicines were correlated with a greater likelihood of abdominal pain, nausea, diarrhea, gallbladder inflammation, and suicidality compared to standard formulations, as well as more frequent hospitalization for those adverse effects

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And insulin resistance itself, when severe enough, can blunt the metabolic improvements these medications provide

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