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The research is strongest in soft-tissue repair and gastrointestinal protection models, with evidence showing benefit in tendon healing, ligament repair, muscle injury, wound healing, angiogenesis, inflammatory modulation, and gut mucosal protection

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137,138 ERS Continuous insulin production and secretion in cells under chronic hyperglycemia and IR result in the overload of protein folding machinery and the accumulation of excessive misfolded or unfolded proteins in the ER, therefore triggering UPR and the ERS

doi: 10.3389/fimmu.2018.02279 26 JinJ-MBaiPHeWWuFLiuX-FHanD-Met al

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Chronic sleep deprivation has been shown to lower glutathione levels and increase oxidative stress, which leads to skin dullness