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However, the use of animal models is expensive, requires a lot of time and expertise, has low throughput potential, poses ethical issues, but most importantly, these models often do not correlate to human systems (Barr-Sinoussi and Montagutelli 2015)

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- [Retatrutide Phase 2 Trial Supplementary Appendix: Drug Preparation]( *New England Journal of Medicine*, 2023

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