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References Deanfield, John et al., Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial, The Lancet, Published on October 22, 2025, DOI: 10.1016/S0140-6736(25)01375-3 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT), ClinicalTrials.gov ID NCT03574597,

The first reports of the eye disease from Danish patients being treated with semaglutide came in the summer of 2024, according to the agency

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In animal models, in addition to GH stimulation, it affects cortisol, prolactin and appetite stimulation (by intensifying ghrelin signaling)