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Important caveat: the human evidence base is thin and largely unreplicated outside the original Russian groups, and most data are preclinical or older clinical work without modern independent confirmation [13]

You roll the tool over your scalp (beware, it doesn't feel good!) and create tiny micropunctures

The sites are reported to be formed by a high-affinity multinuclear iron cluster in which redox-inactive Fe 3+ is bound by oxo and/or hydroxo bridges and is surrounded by catechol groups of NM, and a lower affinity mononuclear iron site in which a single iron ion is six-coordinated by oxygen atoms of catechol moieties, and possibly by water or hydroxo groups (Zecca et al