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Genetic polymorphisms in genes encoding matrix metalloproteinases, collagen synthesis enzymes, or inflammatory mediators could theoretically influence GHK-Cu responsiveness, though systematic investigations of pharmacogenetic determinants remain absent from current literature

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To compare continuous variables among groups, Students t test, Mann-Whitney U test and Friedman test were utilized

it was possible to analyze these adverse events retrospectively through chart review, laboratory values, and imaging results

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