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A review of the two peptides in The American Journal of Sports Medicine this year noted that research studies had yet to generate reliable human data on the peptides' safety, side effects, proper dosage, or which conditions they should or shouldn't be used to treat
doi: 10.3389/fendo.2022.1092837 Received 08 November 2022 Accepted 12 December 2022 Published 04 January 2023 Volume 13 - 2022 Edited by Luna Samanta, Ravenshaw University, India Reviewed by Jelena Djordjevic, Faculty of Biology, University of Belgrade, Serbia
Strategies to minimize immunogenicity include careful peptide design to maintain similarity to natural sequences, appropriate formulation development, and monitoring for antibody formation during clinical development and post-market surveillance
Labs that work with it usually restrict access to trained staff, require proper protective equipment, and store the peptide according to stability guidelines to preserve sample integrity
Further studies showed that berberine enhanced the activities of glutathione peroxidase, glutathione, superoxide dismutase, and catalase, further reducing the activity of acetylcholinesterase and caspase-3, protein carbonyl, and DNA fragmentation in the hippocampus (Sadraie et al., 2019)
