Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration
vemurafenib 5 days/week, 10 mg/kg) and BRAFi+MEKi group (vemurafenib 5 days/week, 10 mg/kg
FDA-approved for T2D (Mounjaro)
Alcohol reduces immune function, as well, due to the loss of glutathione stores
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For determining total glutathione, parasite lysate was mixed with 3 volumes of 5% sulfosalicylic acid (SSA), centrifuged, and the supernatant was directly used
