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A site that is difficult to reach can increase the chance of shaky technique, short hold time, or uncertain placement

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Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request

Journal of Pharmaceutical Sciences 99 , 22002208, doi:10.1002/jps.21989 (2010)